Members of an American scientific research outpost in Antarctica find themselves battling a parasitic alien organism capable of perfectly imitating its victims. They soon discover that this task will be harder than they thought, as they don't know which members of the team have already been assimilated and their paranoia threatens to tear them apart.
FBI Agent Will Graham, who retired after catching Hannibal Lecktor, returns to duty to engage in a risky cat-and-mouse game with Lecktor to capture a new killer.
Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
The hopes and dreams of four ambitious people are shattered when their drug addictions begin spiraling out of control. A look into addiction and how it overcomes the mind and body.